BIOPHYLAXIS
?? ??????? ??????? ? ???????? ??????? ??? ?? ?????? ????????????????? ????????? ????????: ??????? ? ????????? ?????????;
? ?????????????? ??? ?? ???????????????? ???????? ???????

  •     ????? ?????? ????? ????? ??? ????? ????? ?????? ?????????? ??????? ?? ?? ?????? ?????????????????  ????????? ???????? (1-5). ???? ?????? ???? ???????????? ????? ??? ???????, ????? ???????? ??  ?????????????? ???? ????????: ???? ???????? ??????? ????? ?????? ??? ???????????? ????????????? ?? ???? ??????????  ???????????? ??? ???? ? ???????????? ?????? ?? ??????? ???????????????, ?? ??????????? ??? ??????????. ??????? ??????????? ???  ????????? ???????? ???? ???? ??? ???? ??? ???????? ?? ????, ???? ??????? ??????????? ?? ??????????? ??????????.

  •     ??????????? ????? ??? ?? ???? ??????? ????? ???????? ??? ???????????? ???????? ??? ?? ??????? ????  ?????????? ?????? ??????? ??? ??????? ??????. ? ????? ??? ????????????????? ????????? ???????? ?? ????????? ?????????? ???????  ???????? ????? ??? ?????, ??? ???????????? ?? ??????????? ????????????? ???????? (regenerative medicine:) (3).  ???? ??????????? ????? ? ????? ????? ??? ?????? ???????? ?????????  ?????????? ??????? ????  ???????????? ????? ??????????? ????????? (?????????????? & ????????????? ????????? ????? ??? ???????????? ?????? ?????????  ????? ?? ????????? ???????????  (6-10), ????????????? ??????????? ??????? ???? ????????  ????????????? (11), ?????????????? (12), ??????? ??????? ??? ?????  (13) ???????? ????? 1 (14-15), ??????? ??????? ????????? ????????  ?????????? (16), ???). ? ????????? ????? ??? ????????? ???????? ?? ???????????????? ??  ????????????? ?????? ???????? (????????, ??????? ???????? ???????, ?????, ??????? ??? ???????? ?????????, ???.) ?????????? ??  ?????????? ??????, ???????? ?? ?????? ????????  ??? ??????? ??????? ?????? ????????????? ??? ????????????? ????????? ????  ??? ??? ??????? ??????? ????.

  •     ???? ??? ?????????? ??????????? ?????? ???? ??? ??? ???????????? ?? ????????????? ????????, ?????  ????? ?? 2005 ????? ????????? ??????? ???????????? ??? 100 ???????? ??? ????????? ????????, ??? ????? ?????????????? ?????  ???? ???? ??? 200.000 ??????? ????????????????? ????????? ???????? ?? ????????? ????????  ??? ??? ??? 160.000 ??????? ??  ???????? ???????? (3). ? ??????? ????? ????????? ?? ?????????? ??????? ??? ????? ??? ??????  ???????? ??? ????????? ??????.

  •     ???????? ??? ?????????? ?????????????? ????? ???????? ???????????? ??? ?????????, ??? ???????  ?????????? ???????? ?? ????????? ????????. ?????? ??? ??????? ???????????? ?????? ?????????  ????????? ????????  ????????????????? ??????????, ??? ? ???????? ????????? ???? ??? ????????? ???????????? ?????? ????? ?????? ??????? ??? ??????  ?? ??????????????? ???? ??? ??????? ????????????? (1-2, 4-5, 17).

  •     ???? ????????? ?????????? ??? ?????????? ?????????? ??????? ???? ???????? ??? ????????? ????????  ???????, ????? ? ?????? ?????????????? ??????????? ??????? ????????? ??? ????????? ?????, ??????? ?????? ? ?????? ??? ???????  ????? ????????? ??? ?????? ?????????? ??????? ????????????????? ????????? ???????? ??? ??? ?????? ???????? (18). ??? ??????? ????, ? BIOPHYLAXIS ???? ?? ????????? ?????? ?????????? ?? ?? ??????? ??????? ??? ????  ?? ??????? ?? ?????????? ???? ?????????? ?????? ??? ??? ???????? ???.  ? ?????????? ??????? ???? ??? ???????? ????????? ???  ???????? ???? ??? ???????????? ???? ?????????? ????? ??? ??? ??????????? ???? ???????, ?? ??? ????????? ??? ????????? ??????  ????????: ?? ??????? ???? ????????? ?? ?????????? ????????? ??? ???????? ???????? ??? ??? ?????? ??????? ????????? ?????????  ????? ???? ??????? ??? ???????? ????????.

  •     ????????????? ??????? ??? ????????????? ??????? ??????????? ??????????? ????????? ???????? ???  ??????????????? ??????? ??? ????? ???? (19-22) ???????? ???? ??????????? ?? ???? ?? ???????  ???????? ???????? ????? ??? ??????? ??? ????? ????????, ?????????? ?????????????????? ??? ??????? (????? ???? ?????????????  ?????????? ????? ??????? ??????????? ????????? ???????? ??? ???????? ??????????????? ???????), ??? ?????????? ??????? ???????  ????????????, ???. ??? ???? ?????? ?????? ???????, ? ????????????? ??????? ????????? ???????? ???????????? ?? ????????  ???????? ??? ??????? ???????????????? ???? ???????? ??? ?????? ??????????? ????.

  •     ??????????? ????????? ?????????  ??? ????? ????????? ??? ??? ???????????? ???? ?? ???????  ???????????????? ???????? ???????, ????? ????????? ??? ???????? ????? ?????????? ????????? (23)  ?????????? ???? ?? ????? ?? ??????????? ??????, ?? ??? ??????? ???????? ?????? ??? ?? ???? ?? ?????.

  •     ? ??????? ????????? ?????? ????? ??? ????????? ???????? ??? ??????? ????? ? ????? ?? ??????????? ?  ??????? ?????, ?????? ?? ?????????? ??? ???? ??????, ???? ???? ??? ????? ??? ????????????? ?????????. ? ???????????? ???????  ??????? ??????????????? ???????? ??? ??? ??????? ?????? ?? ?????????? ?????????? ???? ???????????? ?????? ?????????, ??????  ?? ???????? ??????????, ??????? ?? ?? ?? ????????? ?? ?????? ?? ????? ?? ?????????????, ????????? ???????? ??????, ? ??????  ????? ?? ??????? ???????, ???? ?? ??????? ? ??????????? ?????????? ??????? ??? ??? ????? ?? ????????? ???? ?? ????????????? ??  ????????? ???????.

  •     ?? ?????? ?????? ?? ????? ???????? ??? ???????? ?????? ?????????? ????? ??? ???????? ????????:  ??  ????????? ?????????? ??????,  ????? ??? ??????? ???? ???????? ??????????? ????????? ????????? ??? ??? ????, ??????????? ?  ???????? ?????????? ??? ??????????? ???????? ??? ????? ( graft-versus-host disease) ??? ??????????????? ???????? ?? ??????  ??????????? ?? ??? ??? ???????, ?????????? ???? ??? ?????? ????????? ??? ???????? ???? ?? ???????????? (24). ???? ????? ??? ????? ???????? ???????????, ?? ?????? ?? ??????? ??????? ??????????? ???  ?????????????? ??? ???????? ?????????, ?????? ?????????? ?????????? ???????? ? ?????? ???????? ??????? ???????? ??? ????????  ????????? ????????, ??????? ?? ????? ?? ?????? ?? ?????????????? ?? ???????????????? ?????????? ?????? ???????? ??? ?????????  ??????????? ???? ??? ??????????: ? ??????????? ?????????? ????????? ??? ???????????? ????????? ???????? ????????? ??????. ?  ????????? ??? ?? ????? ???????? ??????????? ?? ???? ??? ????? ??????? ?????????????? ?????? ?? ???????????????? ????????  ??????? ??????? ??? ??????????? ?????????, ?????? ?? ??????? ??????????? ?????? ?????????????? ??????????: ??? ?????????????  ???????????? ????????? ?? ???? ??? ?????????? (25), ??? ???????? ???? ?? 1 ??? 100 ??????  ??  ????????????? ????? ??? ???????????????? ???? ???? ?????????? ?? ?????????? ?????????, ???? ??? ???????? ????????  ????????????? ??? ???????? (???????????)(17). ?? ?????? ?????? ?? ????????? ??? ??? ????????  ???????? ???????? ??? ?????????? ??? ?????????  ??????? ?????????????? ?????? ??? ???????????????? ???????? ??????? (17).

  •     ?????????? ??????? ????????? ??? ??? ?????? ??? 2008: ? BIOPHYLAXIS ?????????? ??????? ?? ???  ?????????? ??????? (2004/23/??) ??? ??? ????????? ???????? ????????? (??? 51/24.03.08) ??? ?????? ??? ???????? ??????????  ????? ??? ????????. ? ???????????? ??? BIOPHYLAXIS ?.?. ?? ???? ??? ?????????????  ??? ????????????????? ????????? ??????????  ??? ?? ???? ??? ?? ???????? ??????? ?????? ??? ??? ?????? ??? ???? ??????????? ??????? ??????? ????????? "?HMOKRITO?" ???  ???????? ???????? ?????????. ???????????? ?? ????????????? ???????????? ?????????? ?????????? ??? ?? ?????? ????????  ????????????? ?????? ?? ????????????? ?????????? ??? ?????????? ?????. ????????? ??????? ????????? ? ?????????? ??  ????????????? ????? ??????????? ????????? ??? ??????? ???????? ???????? ??? ???? ??? ????????? ???????? ??? ??????????, ??? ?  ?????????? ?? ??? ??????? ??????? ??? ????????? ??????????????? ??????? ??? ????????? ??????, ? ????? ????? ?????????  ????????????? ??? ????????????? ???????.  ?? ???????? ??? ????????, ?????????? ??????? ???????? ??? ?????????? ?????? ?.  ???????? ???????????? ???? 14 ?????????? 2007 ??? ???????? ???? ???????? ??????????????:  ??????? ?? ?? ?????? ???????  ???????, ???????? ????? ???? ????????????, ????????? ?? ??????? ??? ???????? ?????? & ?????????? ???????????, ..., ???  ??????????? ???? ?? ??????????? ???????? ???? ? ???? ??????????? ??? ?? ????????????? ?????????, ? ??? ?????? ??????????, ?  ??? ?????? ??????????????? ??????? ??? ????????? ??????.

    ?? ??????? ?. ??????????, ?/????? ??????????? ????????? ?.?.?.?.?. ??????????
    ?????????? ???????, ??? ?????????? ??? ????????????? ?????????

  • ????????????:
    1.     Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM (2008): Lifetime probabilities of hematopoietic stem  cell transplantation in the U.S. Biol Blood Marrow Transplant.14(3):316-22.
    2.     Watt SM, Austin E, Armitage S (2007): Cryopreservation of hematopoietic stem/progenitor cells for therapeutic  use. Methods Mol Biol. 2007;368:237-59
    3.     Gunning J (2005): Umbilical cord cell banking-implications for the future. Toxicol. Appl. Pharmacol.  207 (2 Suppl) 538-43
    4.     Wright-Kanuth MS, Smith LA (2001) Hematopoietic stem cell transplantation. Clin. Lab. Sci.  14(2):112-7
    5.     Committee on Obstretric Practice: Committee on Genetics (2008): ACOG committee opinion 399 February 2008:  Umbilical cord blood banking.  Obstet Gynecol. 2008 111(2 Pt 1):475-7S
    6.     Furfaro EM, Gaballa MA (2007) Do adult stem cells ameliorate the damaged myocardium? Human cord blood as a  potential source of stem cells. Curr Vasc Pharmacol. 5(1):27-44
    7.     Leor J, Guetta E, Feinberg MS, Galski H, Bar I, Holbova R, Miller L, Zarin P, Castel D, Barbash IM, Nagler A (2006)  Human umbilical cord blood-derived CD133+ cells enhance function and repair of the infarcted myocardium. Stem  Cells 24(6): 1627
    8.     Wu KH, Yang SG, Zhou B, Du WT, Gu DS, Liu PX, Liao WB, Han ZC, Liu YL (2007): Human umbilical cord derived  stem cells for the injured heart. Med Hypotheses. 68(1):94-7
    9.     Sodian R, Lueders C, Kraemer L, Kuebler W, Shakibaei M, Reichart B, Daebritz S, Hetzer R. (2006) Tissue  engineering of autologous human heart valves using cryopreserved vascular umbilical cord cells. Ann Thorac Surg.  81(6):2207-16
    10.     Breymann C, Schmidt D, Hoerstrup SP (2006): Umbilical cord cells as a source of cardiovascular tissue  engineering. Stem Cell Rev. 2(2):87-92.
    11.     Nagaya N, Kangawa K, Kanda M, Uematsu M, Horio T, Fukuyama N, Hino J, Harada-Shiba M, Okumura H, Tabata Y, Mochizuki  N, Chiba Y, Nishioka K, Miyatake K, Asahara T, Hara H, Mori H (2003): Hybrid cell-gene therapy for pulmonary  hypertension based on phagocytosing action of endothelial progenitor cells. Circulation. 108(7):889-95.
    12.     Lee SH, Yoo KH, Sung KW, Kim JY, Cho EJ, Koo HH, Chung SE, Kang SW, Oh SY, Ham DI, Kim YD (2008): Tandem  high-dose chemotherapy and autologous stem cell rescue in children with bilateral advanced retinoblastoma. Bone  Marrow Transplant. Jun 23. [Epub ahead of print]
    13.     Salgado AJ, Oliveira JT, Pedro AJ, Reis RL (2006): Adult stem cells in bone and cartilage tissue  engineering. Curr Stem Cell Res Ther.1(3):345-64
    14.     Shamblott MJ, Clark GO (2004): Cell therapies for type 1 diabetes mellitus. Expert Opin Biol Ther.  4(3): 269-77
    15.     Denner L, Bodenburg Y, Zhao JG, Howe M, Cappo J, Tilton RG, Copland JA, Forraz N, McGuckin C, Urban R (2007):  Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin. Cell Prolif.  40(3):367-80
    16.     Low CB, Liou YC, Tang BL (2008): Neural differentiation and potential use of stem cells from the human  umbilical cord for central nervous system transplantation therapy. J Neurosci Res. 86(8):1670-9
    17.     Hayani ?, Lampeter ?, Viswanatha D, Morgan D, Salvi, SN (2007): First report of autologous cord blood  transplantation in the treatment of a child with leukaemia, Pediatrics 119(1): e296-300
    18.     Samuel GN, Kerridge IH, O'Brien TA (2008): Umbilical cord blood banking: public good or private  benefit? Med J Aust. 188(9):533-5
    19.     Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007): Induction of pluripotent  stem cells from adult human fibroblasts by defined factors. Cell. 131(5):861-72
    20.     Lewitzky M, Yamanaka S (2007): Reprogramming somatic cells towards pluripotency by defined factors.  Curr Opin Biotechnol. 18(5):467-73.
    21.     Takahashi K, Okita K, Nakagawa M, Yamanaka S (2007): Induction of pluripotent stem cells from fibroblast  cultures. Nat Protoc. 2007;2(12):3081-9
    22.     Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S (2008):   Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat Biotechnol.  26(1):101-6
    23.     Kohn DB, Weinberg ??, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, Hanley ME, Annett G, Brooks JS, El-Khoureiy A,  Lawrence K, Wells S, Moen RC, Bastian J, Williams-Herman DE,  Elder M, Wara D, Bowen T, Hershfield MS, Mullen GA, Blaese RM,  Parkman R (1995): Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase  deficiency. Nature Medicine  1, 1017 - 1023.
    24.     ?rora M, Nagaraj S, Wagner JE, Barker JN, Brunstein CG, Burns LJ, Defor TE, McMillan ML, Miller JS, Weisdorf DJ  (2007): Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation  (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB). Biol Blood Marrow  Transplant. 13(10):1145-52
    25.     Fasching K, Panzer S, Haas OA, Marschalek R, Gadner H, Panzer-Grumayer ER.(2000): Presence of clone-specific  antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute  lymphoblastic leukemia. Blood 95 (8): 2772-4.